The Causes, Symptoms, And Treatment Of Cholestasis


Cholestasis is a liver disease that occurs when the flow of bile from your liver is reduced or blocked. Cholestasis slows down digestion, which can lead to fatty deposits and cirrhosis of the liver. In this article, we’ll discuss what causes and symptoms of cholestasis are, along with treatments in case you’re experiencing these symptoms.

What is Cholestasis?

Cholestasis is an umbrella term used to describe any of the following:

1. The blockage of bile flow from the liver.
2. The accumulation of bilirubin in the blood.
3. The yellowing of the skin and eyes as a result of excess bilirubin.
4. A decrease in red blood cells due to obstruction of their migration or due to accumulation of bilirubin.
5. Damage to liver tissue due to long-term high levels of bile salts in the blood.
6. Liver cirrhosis induced by alcohol or hepatitis C infection.
7. Focal ballooning on ultrasound due to obstruction in small venules near the liver (microscopic cirrhosis).
8. Jaundice, a yellowing of the skin and eyes caused by too much bilirubin in the bloodstream.

Some causes of cholestasis are more common than others, but all are capable of causing significant health problems if left untreated. If you’re experiencing any symptoms associated with cholestasis, it’s important to get checked out by your doctor as soon as possible!

Signs and symptoms of Cholestasis

Cholestasis is a liver disease caused by obstruction of bile flow. The most common causes are hepatitis C and biliary atresia, but it can also be caused by other diseases and…

Cholestasis is a liver disease caused by obstruction of bile flow. The most common causes are hepatitis C and biliary atresia, but it can also be caused by other diseases and conditions, such as gallstones. Cholestasis can cause numerous signs and symptoms, which depend on the location and severity of the blockage.

Some common signs and symptoms of cholestasis include jaundice (yellowing of the skin or eyes), darkening of the urine or bowel movements, light yellowing of the stools, loss of appetite, nausea, vomiting, fatigue, clay-colored stools, fever, and abdominal pain. More serious cholestatic conditions may result in rapid development of liver cancer.

Most people with cholestasis will experience only mild to moderate symptoms that gradually improve over time. However, any cholestatic condition can rapidly develop into a more serious condition if left untreated. Treatment usually consists of removing the obstructive material from the liver using

Causes of Cholestasis

There are many causes of cholestasis, which include:

-Cholesterol build-up in the bile and pancreatic ducts
-Agenesis of the biliary tract
-Trauma to the liver
-Chronic pancreatitis
-Cystic fibrosis

The most common cause is cholesterol build-up in the bile and pancreatic ducts. This can be caused by a number of factors, including: lifestyle choices, high cholesterol levels, alcohol consumption, and obesity. Some treatments for cholestasis include dietary changes, drug therapy, and surgery. If the problem is severe, then treatment may involve cholecystectomy (removal of the gallbladder).

Agenesis of the biliary tract is another common cause of cholestasis. This occurs when a section of the biliary tract doesn’t form properly during fetal development. In some cases, this can happen due to infection or injury. Associated symptoms may include fatigue, weight loss, jaundice (yellowing of skin and eyes), and nausea. Treatment typically involves surgery to remove part or all of the affected section of the biliary tract.

How to Treat Cholestasis

Cholestasis is a condition that occurs when the bile flow from the liver is obstructed. The most common causes of cholestasis are injury or cancer of the liver. Symptoms of cholestasis typically include jaundice, nausea, extreme fatigue, and vomiting. Treatment for cholestasis depends on the severity of the condition. Corrective measures may include corticosteroids and oral medications to improve bile flow. In some cases, surgery may be necessary to remove the obstruction.


If you’re experiencing any of the following symptoms, it might be time to get checked out for cholestasis:

  • unexplained weight loss
  • severe itchiness especially in the hands and feet
  • night sweats resulting in a heavy feeling after going to bed
  • rivering eyesight problems
  • diarrhea that lasts more than three days or is accompanied by clay-colored stools
  • persistent nausea or vomiting.


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